Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity

dc.creatorGuzman Oyarzo, Dina
dc.creatorHernandez Montelongo, Jacobo
dc.creatorRosas, Carlos
dc.creatorLeal, Pamela
dc.creatorWeber, Helga
dc.creatorAlvear, Marysol
dc.creatorSalazar, Luis A.
dc.date2022
dc.date2022-04-18T17:05:49Z
dc.date2022-04-18T17:05:49Z
dc.date.accessioned2022-10-18T14:53:24Z
dc.date.available2022-10-18T14:53:24Z
dc.identifierPHARMACEUTICS,Vol.14,,2022
dc.identifierhttps://repositoriodigital.uct.cl/handle/10925/4540
dc.identifier10.3390/pharmaceutics14030484
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4444426
dc.descriptionAlthough polyphenols have great pharmacological potential, the main disadvantage is that they have low bioavailability at the desired site. Thus, the use of biocompatible systems for drug delivery is a strategy that is currently gaining great interest. The objective of this study is to evaluate the effect of microencapsulation of caffeic acid and pinocembrin on the antioxidant and antiangiogenic activity of both polyphenols, by the use of nPSi-beta CD composite microparticles. For this HUVEC, cells were exposed to H2O2 and to treatments with polyphenols in solution and loaded in the composite microparticle. The polyphenols were incorporated into a microparticle using nanoporous silicon, chitosan and a beta-cyclodextrin polymer as the biomaterial. The evaluation of the antiangiogenic effect of the treatments with polyphenols in solution and microencapsulated was carried out through functional tests, and the changes in the expression of target genes associated with the antioxidant pathway and angiogenesis was performed through qPCR. The results obtained show that the caffeic acid and pinocembrin have an antioxidant and antiangiogenic activity, both in solution as microencapsulated. In the caffeic acid, a greater biological effect was observed when it was incorporated into the nPSi-beta CD composite microparticle. Our results suggest that the nPSi-beta CD composite microparticle could be used as an alternative oral drug administration system.
dc.languageen
dc.publisherMDPI
dc.sourcePHARMACEUTICS
dc.subjectantiangiogenic activity
dc.subjectcaffeic acid
dc.subjectpinocembrin
dc.subjectpolyphenols
dc.subjectHUVECs
dc.subjectcontrolled release
dc.subjectnPSi/beta CD microparticle
dc.titleControlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity
dc.typeArticle


Este ítem pertenece a la siguiente institución