dc.creator | González, Andrea | |
dc.creator | Kumar Singh, Sandeep | |
dc.creator | Churruca, Macarena | |
dc.creator | Maccioni Baraona, Ricardo Benjamin | |
dc.date.accessioned | 2022-06-17T17:16:37Z | |
dc.date.accessioned | 2022-10-17T16:48:36Z | |
dc.date.available | 2022-06-17T17:16:37Z | |
dc.date.available | 2022-10-17T16:48:36Z | |
dc.date.created | 2022-06-17T17:16:37Z | |
dc.date.issued | 2021 | |
dc.identifier | Int. J. Mol. Sci. 2022, 23, 4192 | |
dc.identifier | 10.3390/ijms23084192 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/186132 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4421174 | |
dc.description.abstract | Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease characterized by
progressive cognitive impairment, apathy, and neuropsychiatric disorders. Two main pathological
hallmarks have been described: neurofibrillary tangles, consisting of tau oligomers (hyperphosphorylated tau) and Aβ plaques. The influence of protein kinases and phosphatases on the hyperphosphorylation of tau is already known. Hyperphosphorylated tau undergoes conformational
changes that promote its self-assembly. However, the process involving these mechanisms is yet to be
elucidated. In vitro recombinant tau can be aggregated by the action of polyanions, such as heparin,
arachidonic acid, and more recently, the action of polyphosphates. However, how that process occurs
in vivo is yet to be understood. In this review, searching the most accurate and updated literature on
the matter, we focus on the precise molecular events linking tau modifications, its misfolding and
the initiation of its pathological self-assembly. Among these, we can identify challenges regarding
tau phosphorylation, the link between tau heteroarylations and the onset of its self-assembly, as
well as the possible metabolic pathways involving natural polyphosphates, that may play a role in
tau self-assembly | |
dc.language | en | |
dc.publisher | MDPI | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | |
dc.source | International Journal of Molecular Sciences | |
dc.subject | Alzheimer’s disease | |
dc.subject | Tau protein | |
dc.subject | Polyanions | |
dc.subject | Polyphosphates | |
dc.subject | Neurofibrillary tangles | |
dc.title | Alzheimer's disease and tau self-assembly: in the search of the missing link | |
dc.type | Artículos de revistas | |