dc.creator | Cretton, Sylvian | |
dc.creator | Genta Jouve, Gregory | |
dc.creator | Kaiser, Marcel | |
dc.creator | Mäser, Pascal | |
dc.creator | Muñoz, Orlando | |
dc.creator | Bürgi, Thomas | |
dc.creator | Cuendet, Muriel | |
dc.creator | Christen, Philippe | |
dc.date.accessioned | 2022-07-05T20:45:27Z | |
dc.date.accessioned | 2022-10-17T13:09:55Z | |
dc.date.available | 2022-07-05T20:45:27Z | |
dc.date.available | 2022-10-17T13:09:55Z | |
dc.date.created | 2022-07-05T20:45:27Z | |
dc.date.issued | 2021 | |
dc.identifier | Phytochemistry 192 (2021) 112957 | |
dc.identifier | 10.1016/j.phytochem.2021.112957 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/186498 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4417979 | |
dc.description.abstract | Chemical investigation of the alkaloid extract of the aerial parts of Schizanthus tricolor led to the targeted
isolation of 26 hygroline derivatives of which 20 were fully characterized. They have not yet been described in
the literature and their structures were established by 1D and 2D NMR, UV and IR spectroscopy, and HRESIMS.
The configuration was determined by Gauge-Independent Atomic Orbital NMR chemical shift calculations
supported by the advanced statistical method DP4 plus, vibrational circular dichroism, and measurement of
optical rotation. Their anti-trypanosomatid, antiplasmodial and cytotoxic activities were measured. Several
compounds exhibited low micromolar activity against Plasmodium falciparum. None of the identified molecules
was cytotoxic | |
dc.language | en | |
dc.publisher | Elsevier | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | |
dc.source | Phytochemistry | |
dc.subject | Schizanthus tricolor | |
dc.subject | Solanaceae | |
dc.subject | Hygroline derivatives | |
dc.subject | Pyrrolidine alkaloids | |
dc.subject | Antiparasitic activity | |
dc.title | Hygroline derivatives from schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities | |
dc.type | Artículos de revistas | |