Artículos de revistas
Hygroline derivatives from schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities
Fecha
2021Registro en:
Phytochemistry 192 (2021) 112957
10.1016/j.phytochem.2021.112957
Autor
Cretton, Sylvian
Genta Jouve, Gregory
Kaiser, Marcel
Mäser, Pascal
Muñoz, Orlando
Bürgi, Thomas
Cuendet, Muriel
Christen, Philippe
Institución
Resumen
Chemical investigation of the alkaloid extract of the aerial parts of Schizanthus tricolor led to the targeted
isolation of 26 hygroline derivatives of which 20 were fully characterized. They have not yet been described in
the literature and their structures were established by 1D and 2D NMR, UV and IR spectroscopy, and HRESIMS.
The configuration was determined by Gauge-Independent Atomic Orbital NMR chemical shift calculations
supported by the advanced statistical method DP4 plus, vibrational circular dichroism, and measurement of
optical rotation. Their anti-trypanosomatid, antiplasmodial and cytotoxic activities were measured. Several
compounds exhibited low micromolar activity against Plasmodium falciparum. None of the identified molecules
was cytotoxic