info:eu-repo/semantics/article
Synthesis and characterization of a novel series of 1,4-dihydropyridine analogues for larvicidal activity against Anopheles arabiensis
Fecha
2017-09Registro en:
Dharma Rao, Bhaskara D.; Bhandary, Subhrajyoti; Chopra, Deepak; Venugopala, Katharigatta N.; Gleiser, Raquel M.; et al.; Synthesis and characterization of a novel series of 1,4-dihydropyridine analogues for larvicidal activity against Anopheles arabiensis; Wiley Blackwell Publishing, Inc; Chemical Biology & Drug Design; 90; 3; 9-2017; 397-405
1747-0277
CONICET Digital
CONICET
Autor
Dharma Rao, Bhaskara D.
Bhandary, Subhrajyoti
Chopra, Deepak
Venugopala, Katharigatta N.
Gleiser, Raquel M.
Kasumbwe, Kabange
Odhav, Bharti
Resumen
The new-fangled bis(4-substituted benzyl) 4-(4-substitued phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivatives were synthesized by the union of substituted aryl aldehyde, tert-butyl acetoacetate, ammonium carbonate with 4-substituted benzyl alcohol via Hantzsch ester synthesis in aqueous medium under catalyst-free conditions. The newly synthesized compounds were characterized by spectroscopic techniques such as IR, NMR (1H and 13C), ESI mass, elemental analysis, and single-crystal X-ray diffraction. The characterized title compounds were evaluated for the larvicidal activity against Anopheles arabiensis by standard WHO larvicidal assay method using Temephos as standard at 4 μg/ml. The title compounds bis(4-methoxybenzyl) 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate and bis(4-chlorobenzyl) 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate exhibited promising larvicidal activity at 65.6% and 72.2%, respectively, when compared with the standard compound at 98.9%.