info:eu-repo/semantics/article
BNCT of 3 cases of spontaneous head and neck cancer in feline patients
Fecha
2004-11Registro en:
Rao, Mónica; Trivillin, Verónica Andrea; Heber, Elisa Mercedes; Cantarelli, María de los Ángeles; Itoiz, María Elina; et al.; BNCT of 3 cases of spontaneous head and neck cancer in feline patients; Elsevier; Applied Radiation and Isotopes; 61; 5; 11-2004; 947-952
0969-8043
CONICET Digital
CONICET
Autor
Rao, Mónica
Trivillin, Verónica Andrea
Heber, Elisa Mercedes
Cantarelli, María de los Ángeles
Itoiz, María Elina
Nigg, David W.
Jiménez Rebagliati, Raúl Alberto Jorge
Batistoni, Daniel Alberto
Schwint, Amanda Elena
Resumen
Having demonstrated BPA-BNCT induced control of experimental squamous cell carcinomas (SCC) of the hamster cheek pouch mucosa with no damage to normal tissue we explored the feasibility and safety of treating spontaneous head and neck tumors, with particular focus on SCC, of terminal feline patients with low dose BPA-BNCT employing the thermal beam of the RA-1 Reactor within a preclinical context. The biodistribution studies showed that, in all three cases evaluated, BPA delivered absolute boron values to tumor in the range that proved therapeutically useful in the experimental model of SCC. BPA-BNCT studies showed no radiotoxic effects, partial tumor control in terms of impaired growth and partial necrosis, an improvement in clinical condition and prolonged survival beyond the terminal condition of the feline patients at the time of recruitment.