info:eu-repo/semantics/article
Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity
Fecha
2016-08Registro en:
Montoya, Alba; Quiroga, Jairo; Abonia, Rodrigo; Derita, Marcos Gabriel; Sortino, Maximiliano Andrés; et al.; Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity; Molecular Diversity Preservation International; Molecules; 21; 8; 8-2016; 969-988
1420-3049
CONICET Digital
CONICET
Autor
Montoya, Alba
Quiroga, Jairo
Abonia, Rodrigo
Derita, Marcos Gabriel
Sortino, Maximiliano Andrés
Ornelas, Alfredo
Zacchino, Susana Alicia Stella
Insuasty, Braulio
Resumen
Twenty-four new hybrid analogues (15-38) containing 7-chloro-4-aminoquinoline and 2-pyrazoline N-heterocyclic fragments were synthesized. Twelve of the new compounds were evaluated against 58 human cancer cell lines by the U.S. National Cancer Institute (NCI). Compounds 25, 30, 31, 36, and 37 showed significant cytostatic activity, with the most outstanding GI50 values ranging from 0.05 to 0.95 μM. The hybrid compounds (15-38) were also evaluated for antifungal activity against Candida albicans and Cryptococcus neoformans. From the obtained results some structure-activity relationships were outlined.