dc.creator | Alonso, Eliana Noelia | |
dc.creator | Ferronato, María Julia | |
dc.creator | Fermento, María Eugenia | |
dc.creator | Gandini, Norberto Ariel | |
dc.creator | López Romero, Alejandro | |
dc.creator | Guevara, Josefina Alejandra | |
dc.creator | Facchinetti, Maria Marta | |
dc.creator | Curino, Alejandro Carlos | |
dc.date.accessioned | 2019-10-11T18:03:46Z | |
dc.date.accessioned | 2022-10-15T16:13:24Z | |
dc.date.available | 2019-10-11T18:03:46Z | |
dc.date.available | 2022-10-15T16:13:24Z | |
dc.date.created | 2019-10-11T18:03:46Z | |
dc.date.issued | 2018-05-04 | |
dc.identifier | Alonso, Eliana Noelia; Ferronato, María Julia; Fermento, María Eugenia; Gandini, Norberto Ariel; López Romero, Alejandro; et al.; Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells; Impact Journals; Oncotarget; 9; 34; 4-5-2018; 23396-23412 | |
dc.identifier | 1949-2553 | |
dc.identifier | http://hdl.handle.net/11336/85738 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4407630 | |
dc.description.abstract | Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy. This scenario highlights the need for novel compounds with high potential for TNBC treatment. In this regard, natural products are important sources of anticancer drugs. D-Fraction, a proteoglucan extracted from the edible and medicinal mushroom Grifola frondosa (Maitake), is a dietary supplement that has been shown to exert both immunostimulatory and immune-independent antitumoral effects on some cancer types. However, its antitumoral potential in TNBC is unknown. Therefore, we employed TNBC cells to investigate if D-Fraction is able to attenuate their aggressive phenotype. We found that D-Fraction decreases MDA-MB-231 cell viability through apoptosis induction and reduces their metastatic potential. D-Fraction increases cell-cell adhesion by increasing E-cadherin protein levels and β-catenin membrane localization, and increases cell-substrate adhesion. D-Fraction also decreases cell motility by affecting actin cytoskeleton rearrangements, and proteolytic activity of MMP-2 and MMP-9. Furthermore, D-Fraction decreases the invasive capacity of MDA-MB-231 cells. In concordance, D-Fraction retards tumor growth and reduces lung metastases in a xenograft model. Altogether, these results suggest the potential therapeutic role of D-Fraction in aggressive TNBC. | |
dc.language | eng | |
dc.publisher | Impact Journals | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25174&path[]=78890 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.18632/oncotarget.25174 | |
dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | MAITAKE D-FRACTION | |
dc.subject | MUSHROOM | |
dc.subject | TRIPLE-NEGATIVE BREAST CANCER | |
dc.subject | ANTITUMORAL | |
dc.subject | ANTIMETASTATIC | |
dc.title | Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |