info:eu-repo/semantics/article
12α-hydroxy- N -demethyl-sauroxine, a lycodane type alkaloid from Phlegmariurus saururus
Fecha
2019-03Registro en:
Vallejo, Mariana Guadalupe; Corzo, Marcos E.; Ortega, María Gabriela; Agnese, Alicia Mariel; 12α-hydroxy- N -demethyl-sauroxine, a lycodane type alkaloid from Phlegmariurus saururus; Taylor & Francis Ltd; Natural Product Research; 34; 9; 3-2019; 1270-1275
1478-6419
1478-6427
CONICET Digital
CONICET
Autor
Vallejo, Mariana Guadalupe
Corzo, Marcos E.
Ortega, María Gabriela
Agnese, Alicia Mariel
Resumen
12α-hydroxy-N-demethyl-sauroxine (1), another new Lycopodium alkaloid from the Lycodane group, was isolated from Phlegmariurus saururus (Lam.) B. Øllg. (Lycopodiaceae). Elucidation of the chemical structure and relative stereochemistry were stated by spectroscopic data and chemical correlation. In addition, the inhibitory activity on acetylcholinesterase for 1 was determined as well as for N-methyllycodine (2), a derivative with the same nucleus, previously identified in P. saururus (IC50 = 33.8 ± 0.8 μM and 547.5 ± 0.5 μM, respectively) and N-demethylsauroxine (3) whose inhibition in the actual conditions was better than the previously informed.