info:eu-repo/semantics/article
Trypanosoma cruzi DNA in cardiac lesions of Argentinean patients with end-stage chronic Chagas heart disease
Fecha
2004-02Registro en:
Schijman, Alejandro Gabriel; Vigliano, Carlos; Viotti, Rodolfo Jorge; Burgos, Juan Miguel; Brandariz, Silvia; et al.; Trypanosoma cruzi DNA in cardiac lesions of Argentinean patients with end-stage chronic Chagas heart disease; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 70; 2; 2-2004; 210-220
0002-9637
CONICET Digital
CONICET
Autor
Schijman, Alejandro Gabriel
Vigliano, Carlos
Viotti, Rodolfo Jorge
Burgos, Juan Miguel
Brandariz, Silvia
Lococo, Bruno E.
Leze, Maria I-
Levin, Mariano Jorge
Armenti, Hector A.
Resumen
The extent of inflammation, fibrosis, and progression of chronic Chagas heart disease (cChHD) was associated with persistence of parasite DNA in cardiac lesions of necropsies or explants from Argentinean cChHD patients. A Trypanosoma cruzi-based polymerase chain reaction showed a positive result in 1) 15% of cardiac sections with less than 10 mononuclear inflammatory cells/high-power field (440x) (MNC/HPF), 89% with 10-19 MNC/HPF, and 100% with more than 20 MNC/HPF (P < 0.0001); 2) 33% with less than 10% fibrosis, 79% with 10-19% fibrosis, and 100% with more than 20% fibrosis (P < 0.01); 3) 25% of specimens from patients classified in Kuschnir groups 0 and I, 70% in group II and 90% in group III (P < .001); and 4) 45% and 90% of the specimens from cChHD patients without or with heart failure, respectively (P < 0.01). These findings stress the role of the parasite in pathogenesis and disease progression of cChHD.