info:eu-repo/semantics/article
Developmental exposure to bisphenol A alters the differentiation and functional response of the adult rat uterus to estrogen treatment
Fecha
2015-04Registro en:
Vigezzi, Lucía; Bosquiazzo, Veronica Lis; Kass, Laura; Ramos, Jorge Guillermo; Muñoz de Toro, Monica Milagros; et al.; Developmental exposure to bisphenol A alters the differentiation and functional response of the adult rat uterus to estrogen treatment; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 52; 4-2015; 83-92
0890-6238
CONICET Digital
CONICET
Autor
Vigezzi, Lucía
Bosquiazzo, Veronica Lis
Kass, Laura
Ramos, Jorge Guillermo
Muñoz de Toro, Monica Milagros
Luque, Enrique Hugo
Resumen
We assessed the long-term effect of perinatal exposure to bisphenol A (BPA) on the rat uterus and the uterine response to estrogen (E2) replacement therapy. BPA (0.5 or 50. μg/kg/day) was administered in the drinking water from gestational day 9 until weaning. We studied the uterus of female offspring on postnatal day (PND) 90 and 360, and the uterine E2 response on PND460 (PND460-E2). On PND90, BPA-exposed rats showed altered glandular proliferation and α-actin expression. On PND360, BPA exposure increased the incidence of abnormalities in the luminal and glandular epithelium. On PND460-E2, the multiplicity of glands with squamous metaplasia increased in BPA50 while the incidence of glands with daughter glands increased in BPA0.5. The expression of steroid receptors, p63 and IGF-I was modified in BPA-exposed rats on PND460-E2. The long-lasting effects of perinatal exposure to BPA included induction of abnormalities in uterine tissue and altered response to E2 replacement therapy.