info:eu-repo/semantics/article
L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae
Fecha
2004-12Registro en:
Gallardo, Gabriela Laura; Penalba, Nora Liliana; Chacana, Pablo Anibal; Terzolo, Horacio Raúl; Cabrera, Gabriela Myriam; L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae; Springer; World Journal of Microbiology; 20; 6; 12-2004; 609-612
0959-3993
CONICET Digital
CONICET
Autor
Gallardo, Gabriela Laura
Penalba, Nora Liliana
Chacana, Pablo Anibal
Terzolo, Horacio Raúl
Cabrera, Gabriela Myriam
Resumen
A search for bioactive compounds, inhibitors of Paenibacillus larvae, the causal agent of American foulbrood, a honeybees' disease, was carried on. Extracts of two fungal strains, Alternaria brassicicola and Alternaria raphani, isolated from pollen collected from beehives, exhibited a specific inhibitory activity against this bacterium. From these extracts and by means of chromatographic steps and bioassay-guided fractionation, three tetramic acids were isolated. The compounds were identified by spectroscopic methods and the absolute stereochemistry was chemically determined. L-Tenuazonic acid was shown to be responsible for the antibiotic activity. This compound showed a MIC of 32 μg/ml, comparable with that of oxytetracycline, an antibiotic currently used for the prevention of American foulbrood.