info:eu-repo/semantics/article
Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
Fecha
2016-08Registro en:
Eldholm, Vegard; Rieux, Adrien; Monteserin, Johana; Montana Lopez, Juliana; Palmero, Domingo; et al.; Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis; eLife Sciences Publications; eLife; 5; 8-2016; 1-19
2050-084X
CONICET Digital
CONICET
Autor
Eldholm, Vegard
Rieux, Adrien
Monteserin, Johana
Montana Lopez, Juliana
Palmero, Domingo
López, Beatriz Graciela
Ritacco, Gloria Viviana
Didelot, Xavier
Balloux, Francois
Resumen
The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.