info:eu-repo/semantics/article
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits
Fecha
2016-03Registro en:
Reynoso, Marcos Adrian; Daud, Adriana del Valle; Belizán, María Melina Eleonora; Sánchez Riera, Alvaro; Vera, Nancy Roxana; Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits; INTERNATIONAL COMMITTEE OF MEDICAL JOURNAL EDITORS; INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND DRUG RESEARCH; 8; 2; 3-2016; 103-110
0975-248X
CONICET Digital
CONICET
Autor
Reynoso, Marcos Adrian
Daud, Adriana del Valle
Belizán, María Melina Eleonora
Sánchez Riera, Alvaro
Vera, Nancy Roxana
Resumen
Ziziphus mistol Griseb. (Rhamnaceae), popularly known as ?mistol,? is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several argentinean communities. The present study was carried out to investigate the medicinal properties and safety of Ziziphus mistol (mistol) fruits ethanol and aqueous extracts and arrope. Antinociceptive activity was assessed using the formalin, acetic acid-induced writhing and tail-flick tests in rats. Anti-inflammatory effects were determinated through carrageenan induced edema test and cotton pellet-induced granuloma formation, in rats. The safety was evaluated with test of acute toxicity (48 hs) and sub-chronic toxicity (91 days).All extracts (1,000 mg / kg body weight) showed significant inhibition (P <0.05) in the pain and inflammation experimentally induced. In the acute toxicity study, a single dose of 4000 and 8000 mg/kg b.w., produced no mortality and no clinical signs of disease were observed after 48 h. In the sub-chronic toxicity study the extracts no caused significant visible signs of toxicity, nor mortality for 91 consecutive days of treatment. No significant differences were found in relative organ weights and hematological and biochemical parameters between the treated groups and the control groups. Aqueous extract and arrope of Z. mistol fruits could be good source of antinociceptive and anti-inflamatory agents because of its good activity and safety.