info:eu-repo/semantics/article
Dynamic neurocognitive changes in interoception after heart transplant
Fecha
2020-07Registro en:
Salamone, Paula Celeste; Sedeño, Lucas; Legaz, Agustina; Bekinschtein, Tristán Andrés; Martorell Caro, Miguel Angel; et al.; Dynamic neurocognitive changes in interoception after heart transplant; Oxford University Press; Brain Communications; 7-2020; 1-10
2632-1297
CONICET Digital
CONICET
Autor
Salamone, Paula Celeste
Sedeño, Lucas
Legaz, Agustina
Bekinschtein, Tristán Andrés
Martorell Caro, Miguel Angel
Gonzalez Adolfi, Federico
Fraile Vazquez, Matías
Rodríguez Arriagada, Nicolás
Favaloro, Liliana Ethel
Peradejordi Lastras, Margarita Ana
Absi, Daniel O.
García, Adolfo Martín
Favaloro, Roberto René
Ibañez, Agustin Mariano
Resumen
Heart-brain integration dynamics are critical for interoception (i.e., the sensing of body-signals). In this unprecedented longitudinal study, we assessed neurocognitive markers of interoception in patients who underwent orthotopic heart transplants and matched healthy controls. Patients were assessed longitudinally before surgery (T1), a few months later (T2), and a year after (T3). We assessed behavioral (heartbeat detection) and electrophysiological (heartbeat evoked potential) markers of interoception. Heartbeat detection task revealed that pre-surgery (T1) interoception was similar between patients and controls. However, patients were outperformed by controls after heart transplant (T2), but no such differences were observed in the follow-up analysis (T3). Neurophysiologically, although heartbeat evoked potential analyses revealed no differences between groups before the surgery (T1), reduced amplitudes of this event-related potential were found for the patients in the two post-transplant stages (T2, T3). All these significant effects persisted after covariation with different cardiologic measures. In sum, this study brings new insights into the adaptive properties of brain-heart pathways.