info:eu-repo/semantics/article
Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis
Fecha
2005-01Registro en:
Geraldo, Murilo V.; Silber, Ariel Mariano; Pereira, Claudio Alejandro; Uliana, Silvia R.B.; Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis; Wiley Blackwell Publishing, Inc; FEMS Microbiology Letters; 242; 2; 1-2005; 275-280
0378-1097
CONICET Digital
CONICET
Autor
Geraldo, Murilo V.
Silber, Ariel Mariano
Pereira, Claudio Alejandro
Uliana, Silvia R.B.
Resumen
The metabolism of protozoan parasites of the Leishmania genus is strongly based on amino acid consumption, but little is known about amino acid uptake in these organisms. In the present work, we identified a Leishmania amazonensis gene (La-PAT1) encoding a putative amino acid transporter that belongs to the amino acid/auxin permease family, a group of H +/amino acid symporters. This single copy gene is upregulated in amastigotes, the life cycle stage found in the mammalian host. La-PAT1 putative orthologous sequences were identified in Leishmania infantum, Leishmania donovani, Leishmania major and Trypanosoma.