info:eu-repo/semantics/publishedVersion
Glycoprotein Folding
Fecha
2019Registro en:
Couto, Paula Monserrat; Caramelo, Julio Javier; Glycoprotein Folding; Academic Press; 2019; 59-71
978-0-12-849886-6
CONICET Digital
CONICET
Autor
Couto, Paula Monserrat
Caramelo, Julio Javier
Resumen
N-glycosylation is the most drastic and frequent modification of secretory pathway proteins. N-glycans fulfill several biological and structural roles. In the early secretory pathway, these moieties are exploited as an information platform of the folding status and age of glycoproteins. A specialized machinery of chaperones, lectins, glycosidases, and glycosyltransferases generates and interprets this information to ensure a productive folding pathway or eliminate misfolded species.