dc.creator | Krawczyk, Maria del Carmen | |
dc.creator | Blake, Mariano Guillermo | |
dc.creator | Baratti, Carlos Maria | |
dc.creator | Romano, Arturo Gabriel | |
dc.creator | Boccia, Mariano Martín | |
dc.creator | Feld, Mariana | |
dc.date.accessioned | 2020-09-29T17:07:04Z | |
dc.date.accessioned | 2022-10-15T15:07:50Z | |
dc.date.available | 2020-09-29T17:07:04Z | |
dc.date.available | 2022-10-15T15:07:50Z | |
dc.date.created | 2020-09-29T17:07:04Z | |
dc.date.issued | 2015-05 | |
dc.identifier | Krawczyk, Maria del Carmen; Blake, Mariano Guillermo; Baratti, Carlos Maria; Romano, Arturo Gabriel; Boccia, Mariano Martín; et al.; Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation; Pergamon-Elsevier Science Ltd; Neuroscience; 294; 5-2015; 227-237 | |
dc.identifier | 0306-4522 | |
dc.identifier | http://hdl.handle.net/11336/115080 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4400672 | |
dc.description.abstract | Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory reconsolidation of an inhibitory avoidance task in CF-1 mice. We found a retrieval-induced cytosolic ERK2 activation in the hippocampus (HIP) 15. min after memory reactivation, and an inhibition at 45. min. PD098059, a MEK1/2 (MAPK/ERK kinase) inhibitor, administered in the HIP immediately after retrieval impaired memory in a dose-dependent fashion. However, infusions of the highest dose of PD098059 performed 40. min after retrieval enhanced memory in mice trained with a weaker footshock. These results suggest for the first time that ERK2 is involved in memory reconsolidation in a biphasic fashion. Furthermore, the inhibition of ERK could either impair or enhance mice performance depending on ERK state of activation. | |
dc.language | eng | |
dc.publisher | Pergamon-Elsevier Science Ltd | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0306452215002456 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuroscience.2015.03.019 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | ERK | |
dc.subject | INHIBITORY AVOIDANCE | |
dc.subject | MAPK | |
dc.subject | MEMORY RECONSOLIDATION | |
dc.subject | MICE | |
dc.subject | PD098059 | |
dc.title | Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |