An integrative model of cancer cell differentiation with immunotherapy

dc.creatorMargarit, David Hipólito
dc.creatorGonzález, Nadia S.
dc.creatorRomanelli, Lilia Mabel
dc.creatorFendrik, Alejandro José
dc.creatorScagliotti, Ariel Fabricio
dc.creatorReale, Marcela Verónica
dc.date.accessioned2022-05-16T20:31:18Z
dc.date.accessioned2022-10-15T14:53:12Z
dc.date.available2022-05-16T20:31:18Z
dc.date.available2022-10-15T14:53:12Z
dc.date.created2022-05-16T20:31:18Z
dc.date.issued2021-10
dc.identifierMargarit, David Hipólito; González, Nadia S.; Romanelli, Lilia Mabel; Fendrik, Alejandro José; Scagliotti, Ariel Fabricio; et al.; An integrative model of cancer cell differentiation with immunotherapy; IOP Publishing; Physical Biology; 18; 6; 10-2021; 1-17; 066007
dc.identifier1478-3967
dc.identifierhttp://hdl.handle.net/11336/157694
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4399112
dc.description.abstractIn order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship between cancer cells at different differentiation stages and the main immune system cells. For this new system, specific ranges were found where transdifferentiation of differentiated cancer cells can occur. In addition, a specific therapy against cancer stem cells was analysed by simulating cytotoxic cell vaccines. In reference to the latter, the different combinations of parameters that optimize it were studied.
dc.languageeng
dc.publisherIOP Publishing
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://iopscience.iop.org/article/10.1088/1478-3975/ac2e72/meta
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1088/1478-3975/ac2e72
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCANCER IMMUNOTHERAPY
dc.subjectCANCER CELL DIFFERENTIATION
dc.subjectDYNAMICAL SYSTEMS
dc.subjectMATHEMATICAL MODELLING
dc.titleAn integrative model of cancer cell differentiation with immunotherapy
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución