info:eu-repo/semantics/article
α-amination reaction of different ketones mediated by carbohydrate Cu2+ complexes
Fecha
2020-09Registro en:
Rossi, Laura Isabel; Krapacher, Claudio Ricardo; Granados, Alejandro Manuel; α-amination reaction of different ketones mediated by carbohydrate Cu2+ complexes; Elsevier B.V.; Molecular Catalysis; 493; 9-2020; 1-6
2468-8231
CONICET Digital
CONICET
Autor
Rossi, Laura Isabel
Krapacher, Claudio Ricardo
Granados, Alejandro Manuel
Resumen
The α-amination reaction of ketones was studied and the reaction conditions were analysed by green metrics. Propiophenone and two aliphatic ketones, saturated cyclic and acyclic secondary amines were used, carbohydrate Cu2+ complexes were the catalysts to obtain the brominate intermediates. Traditional stirring and ultrasound methods were compared. The use of α-CDCuBr2 complex in the presence of propiophenone, morpholine and O2 was the best condition to carry out the α-amination reaction using a One Pot synthesis, with an 80 % yield of product isolated and no by-product was detected.