info:eu-repo/semantics/article
Chronotherapy of cancer: periodic perturbations in vascular growth and metastasis
Fecha
2019-07Registro en:
Jaime, J.C.; Mesa Álvarez, M.D.; Martín Pardo, Reinaldo Román; Betancourt Mar, J.A.; Cocho, G.; et al.; Chronotherapy of cancer: periodic perturbations in vascular growth and metastasis; Taylor & Francis Ltd; Biological Rhythm Research; 50; 4; 7-2019; 495-504
0929-1016
CONICET Digital
CONICET
Autor
Jaime, J.C.
Mesa Álvarez, M.D.
Martín Pardo, Reinaldo Román
Betancourt Mar, J.A.
Cocho, G.
Mansilla, R.
Nieto Villar, J.M.
Resumen
A non-autonomous model was developed for vascular tumor growth and cancer metastasis under periodic perturbations that simulate chronotherapy. It was found that for a critical amplitude and a perturbation frequency of twice the autonomous frequency in vascular growth, less complex and therefore less robust states are reached and the tumor population decreases. In metastasis, similar results were found for a perturbation frequency equal to the autonomous frequency. In metastasis, similar behaviors occur, for a perturbation’s frequency equal to the fundamental frequency of system.