info:eu-repo/semantics/article
Total Synthesis and Tentative Structural Elucidation of Cryptomoscatone E3: Interplay of Experimental and Computational Studies
Fecha
2015-10Registro en:
Novaes, Luiz F. T.; Sarotti, Ariel Marcelo; Pilli, Ronaldo A.; Total Synthesis and Tentative Structural Elucidation of Cryptomoscatone E3: Interplay of Experimental and Computational Studies; American Chemical Society; Journal of Organic Chemistry; 80; 24; 10-2015; 12027-12037
0022-3263
CONICET Digital
CONICET
Autor
Novaes, Luiz F. T.
Sarotti, Ariel Marcelo
Pilli, Ronaldo A.
Resumen
A successful combination of computational chemistry and total synthesis was explored to tentatively elucidate the absolute configuration of cryptomoscatone E3, a polyketide isolated from the Brazilian tree Cryptocarya mandiocanna. Two independent synthetic approaches are discussed based on asymmetric allylation, ring closing metathesis, and aldol reactions.