info:eu-repo/semantics/article
Effect of different C3-aryl substituents on the antioxidant activity of 4-hydroxycoumarin derivatives
Fecha
2011-11Registro en:
Rodríguez, Sergio Antonio; Nazareno, Mónica Azucena; Baumgartner, Maria Teresa del V.; Effect of different C3-aryl substituents on the antioxidant activity of 4-hydroxycoumarin derivatives; Pergamon-Elsevier Science Ltd; Bioorganic & Medicinal Chemistry; 19; 21; 11-2011; 6233-6238
0968-0896
CONICET Digital
CONICET
Autor
Rodríguez, Sergio Antonio
Nazareno, Mónica Azucena
Baumgartner, Maria Teresa del V.
Resumen
The antioxidant activity of 4-hydroxycoumarin synthetic derivatives and 4-methylumbelliferone were determined taking 4-hydroxycoumarin as the reference compound. Six 3-aryl-4-hydroxycoumarin derivatives were synthesized from 4-hydroxycoumarin as precursor in order to evaluate changes in their antioxidant properties due to C3-aryl substituent nature. Free radical scavenging capacities of these compounds against two different species DPPH and ABTS+ and the protecting ability towards the b-carotene-linoleic acid co-oxidation enzymatically induced by lipoxygenase were measured. In addition, the relationship between the activities of these molecules against DPPH radical and the bond dissociation energy of O-H (BDE) calculated using methods of computational chemistry was evaluated.