dc.creator | Mandal, Pinaki | |
dc.creator | Pujol, Carlos Alberto | |
dc.creator | Damonte, Elsa Beatriz | |
dc.creator | Ghosh, Tuhin | |
dc.creator | Ray, Bimalendu | |
dc.date.accessioned | 2018-12-12T20:30:38Z | |
dc.date.accessioned | 2022-10-15T12:34:13Z | |
dc.date.available | 2018-12-12T20:30:38Z | |
dc.date.available | 2022-10-15T12:34:13Z | |
dc.date.created | 2018-12-12T20:30:38Z | |
dc.date.issued | 2010-03 | |
dc.identifier | Mandal, Pinaki; Pujol, Carlos Alberto; Damonte, Elsa Beatriz; Ghosh, Tuhin; Ray, Bimalendu; Xylans from Scinaia hatei: Structural features, sulfation and anti-HSV activity; Elsevier Science; International Journal of Biological Macromolecules; 46; 2; 3-2010; 173-178 | |
dc.identifier | 0141-8130 | |
dc.identifier | http://hdl.handle.net/11336/66379 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4386526 | |
dc.description.abstract | Natural compounds offer interesting pharmacological perspectives for antiviral drug development with regard to broad-spectrum antiviral properties and novel modes of action. In this study, we have analyzed alkali-extracted xylan of Scinaia hatei. Alkali extraction of this red alga yielded a xylan shown to have a molecular mass of 120kDa and a linear structure of (1→4)-linked β-d-xylopyranosyl residues. Derivatives (S1, S2, S3 and S4) generated by chemical sulfation from this macromolecule had degree of sulfation between 0.93 and 1.95, and contained strong anti-HSV activity with inhibitory concentration 50% (IC50) from 0.22 to 1.37μg/ml. Furthermore, they had no direct inactivating effect on virions in a virucidal assay. Sulfate groups account for their in vitro antiviral activity. Interestingly, sulfated xylans already exerted anti-HSV activity when only pre-incubated with the cultured cells prior to infection, thus pointing to a main inhibitory effect on viral entry. © 2009 Elsevier B.V. | |
dc.language | eng | |
dc.publisher | Elsevier Science | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0141813009002669 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.ijbiomac.2009.12.003 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | ANTIVIRAL ACTIVITY | |
dc.subject | HERPES SIMPLEX VIRUS | |
dc.subject | LIAGORACEAE | |
dc.subject | SCINAIA HATEI | |
dc.subject | SULFATION | |
dc.subject | XYLAN | |
dc.title | Xylans from Scinaia hatei: Structural features, sulfation and anti-HSV activity | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |