info:eu-repo/semantics/article
The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Platelet Physiology
Fecha
2021-05Registro en:
Gresele, Paolo; Falcinelli, Emanuela; Bury, Loredana; Pecci, Alessandro; Alessi, Marie Christine; et al.; The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Platelet Physiology; Wiley Blackwell Publishing, Inc; Journal of Thrombosis and Haemostasis; 19; 5; 5-2021; 1364-1371
1538-7933
CONICET Digital
CONICET
Autor
Gresele, Paolo
Falcinelli, Emanuela
Bury, Loredana
Pecci, Alessandro
Alessi, Marie Christine
Borhany, Munira
Heller, Paula Graciela
Santoro, Cristina
Cid, Ana Rosa
Orsini, Sara
Fontana, Pierre
De Candia, Erica
Podda, Gianmarco
Kannan, Meganathan
Jurk, Kerstin
Castaman, Giancarlo
Falaise, Céline
Guglielmini, Giuseppe
Noris, Patrizia
Zaninetti, Carlo
Fiore, Mathieu
Tosseto, Alberto
Zuñiga, Pamela
Miyazaki, K.
Dupuis, Arnaud
Hayward, Catherine
Casonatto, Alessandra
Grandone, Elvira
Mazzuconi Maria Gabriella
James, Paula
Fabris, Fabrizio
Henskens, Yvonne
Napolitano, Mariasanta
Curnow, Jennifer
Gkalea, Vasiliki
Fedor, Marian
Lambert, Michele P.
Zieger, Barbara
Barcella, Luca
Cosmi, Benilde
Giordano, Paola
Porri, Claudia
Melazzini, Federica
Abid, Madiha
Glembotsky, Ana Claudia
Ferrara, Gracia
Russo, Alessandra
Deckmyn, Hans
Frelinger, Andrew L.
Harrison, Paul
Mezzano, Diego
Mumford, Andrew D.
Lordkipanidzé, Marie
Resumen
Background: The ISTH Bleeding Assessment Tool (ISTH-BAT) has been validated for clinical screening of suspected von Willebrand disease (VWD) and for bleeding prediction. Recently it has been validated for subjects with inherited platelet disorders (IPD) (BAT-VAL study). Objectives: To determine whether the ISTH-BAT bleeding score (BS) predicts subsequent bleeding events requiring treatment in IPD patients. Methods: Patients with IPD, type 1 VWD (VWD-1) and age- and sex-matched healthy controls enrolled in the BAT-VAL study were prospectively followed-up for 2 years and bleeding episodes requiring treatment were recorded. Results: Of the 1098 subjects initially enrolled, 955 were followed-up and 124 suffered hemorrhages during follow-up, 60% of whom had inherited platelet function disorders (IPFD). Total number of events was significantly higher in IPFD (n = 235) than VWD-1 (n = 52) or inherited thrombocytopenia (IT; n = 20). Events requiring transfusions were 66% in IPFD, 5.7% in VWD-1, and 3% in IT. Baseline BS was significantly higher in IPFD patients with a bleeding event at follow-up than in those without (p <.01) and the percentage of subjects suffering a bleeding event increased proportionally to baseline BS quartile. A significant association between the BS and the chance of suffering severe bleeding was found in the overall, IPFD, and VWD-1 populations. Similar results were obtained for the pediatric population. Conclusions: Inherited platelet function disorder patients with high BS at enrollment are more likely to suffer from bleeding events requiring treatment at follow-up. Moreover, the higher the baseline BS quartile the greater the incidence of subsequent events, suggesting that independently from diagnosis a high BS is associated with a greater risk of subsequent hemorrhage.
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Análisis crítico de un artículo: Critical appraisal: Band ligation and propranolol are equally effective for primary prevention of variceal bleeding. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W et al; German Study Group for the Primary Prophylaxis of Variceal Bleeding. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72.
Larrondo G,Francisco Javier; Manríquez M,Juan Jorge -
The Utility Of International Society On Thrombosis And Haemostasis-bleeding Assessment Tool And Other Bleeding Questionnaires In Assessing The Bleeding Phenotype In Two Platelet Function Defects
Kaur; Harmanpreet; Borhany; Munira; Azzam; Hanan; Costa-Lima; Carolina; Ozelo; Margareth; Othman; Maha -
The Utility Of International Society On Thrombosis And Haemostasis-bleeding Assessment Tool And Other Bleeding Questionnaires In Assessing The Bleeding Phenotype In Two Platelet Function Defects.
Kaur H; Borhany M; Azzam H; Costa-Lima C; Ozelo M; Othman M.