info:eu-repo/semantics/article
Resistance to β-lactams in Streptococcus pneumoniae
Fecha
2021-07Registro en:
Von Specht, Martha Helena; García Gabarrot, Gabriela; Mollerach, Marta Eugenia; Bonofiglio, Laura; Gagetti, Paula Silvana; et al.; Resistance to β-lactams in Streptococcus pneumoniae; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 53; 7-2021; 1-6
1851-7617
1851-7617
CONICET Digital
CONICET
Autor
Von Specht, Martha Helena
García Gabarrot, Gabriela
Mollerach, Marta Eugenia
Bonofiglio, Laura
Gagetti, Paula Silvana
Kaufman, Sara
Vigliarolo, Laura
Toresani, Silvia María Ines
Lopardo, Horacio Angel
Resumen
Streptococcus pneumoniae is an important causal agent of pneumonia, meningitis, sepsis, bacteremia, and otitis media. Penicillin resistance rates in S. pneumoniae have remained stable in Argentina in the last years. In the late ?90s more isolates with MIC of penicillin ≥2 μg/ml were observed; however, their frequency has decreased in recent years. The phenotypic expression of penicillin resistance is due to a modification in penicillin-binding proteins associated with a mosaic structure in the coding genes. The expansion of successful resistant clones varies among the different regions and is influenced by the use of antibiotics, vaccines, particularly conjugated ones, as well as population density. Parenteral treatment with high doses of penicillin G continues to be effective for the treatment of pneumonia and bacteremia, oral aminopenicillins for otitis media and sinusitis and third generation cephalosporins for meningitis.