info:eu-repo/semantics/article
Helicobacter pylori bab genes during chronic colonization
Fecha
2011-08-30Registro en:
Matteo, Mario José; Armitano, Rita Ines; Borromeo, Mariela Alejandra; Wonaga, Andres Dario; Olmos, Martín Javier; et al.; Helicobacter pylori bab genes during chronic colonization; e-Century Publishing; International journal of molecular epidemiology and genetics; 2; 3; 30-8-2011; 286-291
1948-1756
CONICET Digital
CONICET
Autor
Matteo, Mario José
Armitano, Rita Ines
Borromeo, Mariela Alejandra
Wonaga, Andres Dario
Olmos, Martín Javier
Catalano, Mariana
Resumen
Helicobacter pylori BabA adhesin metastability could yield variants with potential for periodic activation and deactivation of their mediated adherence. babA/B or babB/A chimeras could play an important role in translational regulation. We investigated the frequency of different bab gene profiles in paired isolates from antrum and corpus recovered from patients with chronic gastritis. Isolates from 174 biopsies from 34 patients were included, and bab genes at the three common chromosomal loci were investigated. Inter-micro-niche variation was found in 1/4 patients, counting duplicate copies of babA or babB, babB/A or babA/B chimeras, opposite location of babA and babB or babC and babB, and absence of babB ATG translational codon. Truncated BabA was identified in 2/34 patients without inter-micro-niche variation. Isolates from 12/34 patients harbored babA/B or babB/A chimeras -either in one, several or all micro-niches indicating that chimera formation is a common mechanism to control BabA expression. To note, babA gene was absent in 11/34 patients, and in this population, babA/B chimeras which lack expression predominated over babB/A, able to exhibit Leb binding phenotype.