info:eu-repo/semantics/article
Synthesis of aromatic stigmastanes: Application to the synthesis of aromatic analogs of brassinosteroids
Fecha
2012-05Registro en:
Acebedo, Sofía Lorena; Alonso, Fernando; Ramirez, Javier Alberto; Galagovsky, Lydia Raquel; Synthesis of aromatic stigmastanes: Application to the synthesis of aromatic analogs of brassinosteroids; Pergamon-Elsevier Science Ltd; Tetrahedron; 68; 19; 5-2012; 3685-3691
0040-4020
CONICET Digital
CONICET
Autor
Acebedo, Sofía Lorena
Alonso, Fernando
Ramirez, Javier Alberto
Galagovsky, Lydia Raquel
Resumen
In this paper, we report the first synthesis of aromatic analogs of brassinosteroids. In order to accomplish this task, we explored two different synthetic approaches, which involved demethylation of the C-19 of stigmasterol to yield A-ring aromatic 3-hydroxystigmastanes. One of the new aromatic analogs showed a reduced but significant bioactivity when compared to the natural hormones.