Loss of the tRNA Lys CUU encoding gene, Chr-11 tRNA-Lys-CUU, is not associated with Type 2 diabetes mellitus

dc.creatorYang, Pablo
dc.creatorBeltramo, Dante Miguel
dc.creatorDe Pouplana, Lluís Ribas
dc.creatorSoria, Néstor Walter
dc.creatorTorres, Adrián Gabriel
dc.date.accessioned2020-08-31T14:09:32Z
dc.date.accessioned2022-10-15T10:59:04Z
dc.date.available2020-08-31T14:09:32Z
dc.date.available2022-10-15T10:59:04Z
dc.date.created2020-08-31T14:09:32Z
dc.date.issued2019-03
dc.identifierYang, Pablo; Beltramo, Dante Miguel; De Pouplana, Lluís Ribas; Soria, Néstor Walter; Torres, Adrián Gabriel; Loss of the tRNA Lys CUU encoding gene, Chr-11 tRNA-Lys-CUU, is not associated with Type 2 diabetes mellitus; Future Medicine; Biomarkers In Medicine; 13; 4; 3-2019; 259-266
dc.identifier1752-0363
dc.identifierhttp://hdl.handle.net/11336/112715
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4378341
dc.description.abstractTo investigate the presence/absence of the Chr-11 tRNA-Lys-CUU gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM). We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels, glycosylated hemoglobin, triglycerides, etc.), and performed a genotypic profiling of Chr-11 tRNA-Lys-CUU by polymerase chain reaction analyses. Approximately one third of the population lacked Chr-11 tRNA-Lys-CUU. We did not observe a statistically significant association between the presence/absence of Chr-11 tRNA-Lys-CUU and T2DM. Conclusion: The genotypic distribution of Chr-11 tRNA-Lys-CUU in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition.
dc.languageeng
dc.publisherFuture Medicine
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/abs/10.2217/bmm-2018-0322?af=R
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2217/bmm-2018-0322
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBIOMARKER
dc.subjectGENE TRANSLATION
dc.subjectGENOTYPIC PROFILING
dc.subjectINSULIN
dc.subjectPCR
dc.subjectT2DM
dc.subjectTRNA
dc.subjectTRNA GENE
dc.subjectTRNA-LYS-CUU
dc.subjectTYPE 2 DIABETES MELLITUS
dc.titleLoss of the tRNA Lys CUU encoding gene, Chr-11 tRNA-Lys-CUU, is not associated with Type 2 diabetes mellitus
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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