info:eu-repo/semantics/article
Differential expression of cyclins mRNA in neural tissues of BoHV-1- and BoHV-5- infected cattle
Fecha
2019-11Registro en:
Marin, Maia Solange; Burucúa, Mercedes María; Rensetti, Daniel Ernesto; Rosales Hurtado, Juan José; Odeón, Anselmo; et al.; Differential expression of cyclins mRNA in neural tissues of BoHV-1- and BoHV-5- infected cattle; Academic Press Ltd - Elsevier Science Ltd; Microbial Pathogenesis; 136; 11-2019
0882-4010
CONICET Digital
CONICET
Autor
Marin, Maia Solange
Burucúa, Mercedes María
Rensetti, Daniel Ernesto
Rosales Hurtado, Juan José
Odeón, Anselmo
Pérez, Sandra
Resumen
Bovine alphaherpesvirus types 1 (BoHV-1) and 5 (BoHV-5) are closely related alphaherpesviruses. BoHV-5 causes non-suppurative meningoencephalitis in calves. BoHV-1 is associated with several syndromes and, occasionally, can cause encephalitis. Although both viruses are neurotropic and they share similar biological properties, it is unknown why these alphaherpesviruses differ in their ability to cause neurological disease. Neural tissue samples were collected from BoHV-1- and BoHV-5-intranasally inoculated calves during acute infection, latency and reactivation and the levels of cyclins mRNA expression were analyzed by qRT-PCR. Striking differences in the levels of cyclins mRNA were particularly detected in trigeminal ganglion (TG). The expression levels of cyclins in TG during BoHV-5 latency suggest that these viruses utilize different strategies to persist in the host. It is apparent that a relationship between virus loads and cyclin mRNA levels can be established only during acute infection and other factors might be involved in the regulation of cell cycle components during BoHV latency and reactivation. Bovine alphaherpesviruses neuropathogenicity might be influenced by the differential control of cell cycle components by these herpesviruses. This is the first report on BoHV-5 modulation of cyclins expression in neural tissues from its natural host.