info:eu-repo/semantics/article
Modeling the Role of Gap Junction Transport Characteristics in the Action Potential Propagation
Fecha
2018-09Registro en:
Irurzun, Isabel Maria; Defeo, Magdalena Maria; Modeling the Role of Gap Junction Transport Characteristics in the Action Potential Propagation; Cornell University; arXiv.org; 9-2018; 1-12
2331-8422
CONICET Digital
CONICET
Autor
Irurzun, Isabel Maria
Defeo, Magdalena Maria
Resumen
We generalize the Cable Model to describe the transport characteristics of the gap junctions coupling adjacent cells in the heart muscle. Our model takes into account recent experimental information about the time dependence of the junctional current and modifies the connections between cells. It can be used with whatever excitable model is used to represent the cell. We show that by modulating the gap junction transport characteristics, it is possible to either suppress or produce meandering of spiral waves, a state associated with cardiac arrhythmia.