info:eu-repo/semantics/article
Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta)
Fecha
2002-12Registro en:
Mazunder, Supata; Ghosal, Prodyut K.; Pujol, Carlos Alberto; Carlucci, Maria Josefina; Damonte, Elsa Beatriz; et al.; Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta); Elsevier Science; International Journal of Biological Macromolecules; 31; 12-2002; 87-95
0141-8130
CONICET Digital
CONICET
Autor
Mazunder, Supata
Ghosal, Prodyut K.
Pujol, Carlos Alberto
Carlucci, Maria Josefina
Damonte, Elsa Beatriz
Ray, Bimalendu
Resumen
Polysaccharides were sequentially extracted from the agarophyte Gracilaria corticata. Chemical analysis combined with infrared spectroscopy showed that the cold water extracted material consists mainly of a high molecular weight sulfated galactan. Most of the sulfate groups are alkali labile and are located at C-4 of the 1,3-linked D-galactose units and C-6 of the 1,4-linked L-galactose residues. The autoclaved extracts contain agar type polysaccharide having a high pyruvate content and a variable degree of methylation, but were contaminated with floridean starch. 1 H-NMR studies indicate that methoxyl groups, when present, occur at C-6 of the 1,3-linked D-galactose units and C-2 of the 1,4-linked L-galactose residues of agar polymer. Bioassays showed that a high molecular weight galactan sulfate, exhibited selective antiviral activity against herpes simplex virus types 1 and 2, likely due to an inhibition of the initial virus attachment to the host cell.