A combined RCM-Bischler-Napieralski strategy towards the synthesis of the carbon skeleton of excentricine and related stephaoxocanes

Abstract

A convenient synthetic approach to a cyclodeca[ij]isoquinoline derivative, which embodies the carbon skeleton of excentricine and related stephaoxocanes, is described. The synthesis involves the combined use of ring closing metathesis and Bischler-Napieralski cyclizations for the construction of the homocyclic and nitrogen-bearing rings, respectively.