info:eu-repo/semantics/article
Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging
Fecha
2021-08Registro en:
Tomar, Ankit Singh; Finger, Paul T.; Gallie, Brenda; Kivelä, Tero; Mallipatna, Ashwin; et al.; Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging; B M J Publishing Group; British Journal Of Ophthalmology; 2021; 8-2021; 1-6
0007-1161
CONICET Digital
CONICET
Autor
Tomar, Ankit Singh
Finger, Paul T.
Gallie, Brenda
Kivelä, Tero
Mallipatna, Ashwin
Zhang, Chengyue
Zhao, Junyang
Wilson, Matthew
Brennan, Rachel
Burges, Michala
Kim, Jonathan
Berry, Jesse L.
Jubran, Rima
Khetan, Vikas
Ganeshan, Suganeswari
Yarovoy, Andrey
Yarovaya, Vera
Kotova, Elena
Volodin, Denis
Yousef, Yacoub
Nummi, Kalle
Ushakova, Tatiana L.
Yugay, Olga V.
Polyakov, Vladimir G
Ramirez Ortiz, Marco Antonio
Esparza Aguiar, Elizabeth
Chantada, Guillermo Luis
Schaiquevich, Paula Susana
Fandiño, Adriana Cristina
Yam, Jason C.
Resumen
Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 and December 2013. 1054 RB eyes with vitreous or subretinal seeds from 18 ophthalmic oncology centres, in 13 countries within six continents were analysed. Local treatment failure was defined as the use of secondary enucleation or external beam radiation therapy (EBRT) and was estimated with the Kaplan-Meier method. Results Clinical category cT2b included 1054 eyes. Median age at presentation was 16.0 months. Of these, 428 (40.6%) eyes were salvaged, and 430 (40.8%) were treated with primary and 196 (18.6%) with secondary enucleation. Of the 592 eyes that had complete data for globe salvage analysis, the distribution of seeds was focal in 143 (24.2%) and diffuse in 449 (75.8%). The 5-year Kaplan-Meier cumulative globe-salvage (without EBRT) was 78% and 49% for eyes with focal and diffuse RB seeding, respectively. Cox proportional hazards regression analysis confirmed a higher local treatment failure risk with diffuse seeds as compared with focal seeds (hazard rate: 2.8; p<0.001). There was insufficient evidence to prove or disprove an association between vitreous seed type and local treatment failure risk(p=0.06). Conclusion This international, multicentre, registry-based analysis of RB eyes affirmed that eyes with diffuse intraocular distribution of RB seeds at diagnosis had a higher risk of local treatment failure when compared with focal seeds. Subclassification of AJCC RB category cT2b into focal vs diffuse seeds will improve prognostication for eye salvage.