dc.creatorKhodarahmi, Reza
dc.creatorKhateri, Shaya
dc.creatorAdibi, Hadi
dc.creatorNasirian, Vahid
dc.creatorHedayati, Mehdi
dc.creatorFaramarzi, Elahe
dc.creatorSoleimani, Shokoufeh
dc.creatorGoicoechea, Hector Casimiro
dc.creatorJalalvand, Ali Reza
dc.date.accessioned2021-03-01T18:34:21Z
dc.date.accessioned2022-10-15T10:22:43Z
dc.date.available2021-03-01T18:34:21Z
dc.date.available2022-10-15T10:22:43Z
dc.date.created2021-03-01T18:34:21Z
dc.date.issued2019-09-01
dc.identifierKhodarahmi, Reza; Khateri, Shaya; Adibi, Hadi; Nasirian, Vahid; Hedayati, Mehdi; et al.; Chemometrical-electrochemical investigation for comparing inhibitory effects of quercetin and its sulfonamide derivative on human carbonic anhydrase II: Theoretical and experimental evidence; Elsevier Science; International Journal of Biological Macromolecules; 136; 1-9-2019; 377-385
dc.identifier0141-8130
dc.identifierhttp://hdl.handle.net/11336/127048
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4375150
dc.description.abstractThis paper reports results of a valuable study on investigation of inhibitory effects of the sulfonamide derivative of quercetin (QD) on human carbonic anhydrase II (CA-II) by electrochemical and chemometrical approaches. To achieve this goal, a glassy carbon electrode (GCE) was chosen as the sensing platform and different electrochemical techniques such as cyclic voltammetry (CV), differential pulse voltammetry (DPV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) were used to investigate and comparing inhibitory effects of quercetin (Q) and QD on CA-II. By the use of EQUISPEC, SPECFIT, SQUAD and REACTLAB as efficient hard-modeling algorithms, bindings of Q and QD with CA-II were investigated and the results confirmed that the QD inhibited the CA-II stronger than Q suggesting a highly relevant role of QD's-SO2NH2 group in inhibiting activity and also was confirmed by docking studies. Finally, a novel EIS technique based on interaction of Q and CA-II was developed for sensitive electroanalytical determination of CA-II and in this section of our study, the sensitivity of the developed electroanalytical methodology was improved by the modification of the GCE was with multi-walled carbon nanotubes-ionic liquid.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0141813019335317
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijbiomac.2019.06.093
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHUMAN CARBONIC ANHYDRASE II
dc.subjectQUERCETIN
dc.subjectQUERCETIN DERIVATIVE
dc.titleChemometrical-electrochemical investigation for comparing inhibitory effects of quercetin and its sulfonamide derivative on human carbonic anhydrase II: Theoretical and experimental evidence
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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