info:eu-repo/semantics/article
Photothermal effect by 808-nm laser irradiation of melanin: A proof-of-concept study of photothermal therapy using b16-f10 melanotic melanoma growing in BALB/c mice
Fecha
2019-06Registro en:
Colombo, Lucas Luis; Vanzulli, Silvia I.; Blázquez Castro, Alfonso; Terrero, Clara Sanchez; Stockert, Juan C.; Photothermal effect by 808-nm laser irradiation of melanin: A proof-of-concept study of photothermal therapy using b16-f10 melanotic melanoma growing in BALB/c mice; Optical Society of America; Biomedical Optics Express; 10; 6; 6-2019; 2932-2941
2156-7085
CONICET Digital
CONICET
Autor
Colombo, Lucas Luis
Vanzulli, Silvia I.
Blázquez Castro, Alfonso
Terrero, Clara Sanchez
Stockert, Juan C.
Resumen
The photothermal effect is undergoing great interest due to advances in new photosensitizing materials and better-suited light sources, but studies are frequently hampered by the need to employ exogenous photothermal agents and expensive irradiation devices. Here we present a simple strategy based on direct NIR irradiation of the melanin pigment with a commercial 808-nm laser pointer. Proof-of-concept studies showed efficient photothermal effects on melanin in vitro and in vivo. After NIR irradiation, BALB/c mice bearing B16-F10 melanotic melanoma tumors revealed severe histopathological damage and massive necrosis in melanin-containing tumor tissue, while surrounding healthy tissues showed no damage. Therefore, the feasibility of this approach may allow implementing direct procedures for photothermal therapy of pigmented tumors.