info:eu-repo/semantics/publishedVersion
PD-L1 expression is induced on cytokine-stimulated human NK cells and contributes to IFN-γ production
Fecha
2019Registro en:
PD-L1 expression is induced on cytokine-stimulated human NK cells and contributes to IFN-γ production; LVII Reunión Científica Anual de la Sociedad Argentina de Inmunología; Tucumán; Argentina; 2019
CONICET Digital
CONICET
Autor
Sierra, Jessica Mariel
Secchiari, Florencia
Nuñez, Sol Yanel
Regge, María Victoria
Friedrich, Adrián David
Santilli, Cecilia
Domaica, Carolina Ines
Zwirner, Norberto Walter
Fuertes, Mercedes Beatriz
Resumen
Natural Killer (NK) cells are critical effectors against tumor and virus-infected cells, and their activity is modulated by multiple inhibitory and activating receptors and cytokines. Tumor-experienced NK cells express high levels of PD-L1, and PD-L1+ NK cells inhibit T cell priming. PD-L1 cell-intrinsic signaling pathways were described in tumor cells. The objective of this work was to study PD-L1 expression on cytokine-stimulated human NK cells and to evaluate PD-L1-mediated regulation of NK cell effector functions.