info:eu-repo/semantics/article
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
Fecha
2006-03-15Registro en:
Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; et al.; Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents; Elsevier; Bioorganic & Medicinal Chemistry; 14; 6; 15-3-2006; 1851-1862
0968-0896
CONICET Digital
CONICET
Autor
Suvire, Fernando Daniel
Sortino, Maximiliano Andrés
Kouznetsov, Vladimir V.
Vargas M, Leonor Y.
Zacchino, Susana Alicia Stella
Cruz, Uriel Mora
Enriz, Ricardo Daniel
Resumen
The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.