info:eu-repo/semantics/article
Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies
Fecha
2005-07Registro en:
Vignaduzzo, Silvana Edit; Maggio, Ruben Mariano; Castellano, Patricia Margarita; Kaufman, Teodoro Saul; Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies; Springer Heidelberg; Analytical and Bioanalytical Chemistry; 382; 7; 7-2005; 1711-1714
1618-2642
CONICET Digital
CONICET
Autor
Vignaduzzo, Silvana Edit
Maggio, Ruben Mariano
Castellano, Patricia Margarita
Kaufman, Teodoro Saul
Resumen
A new, repeatable, and rapid method has been developed for resolution of binary mixtures of acetaminophen and diclofenac with minimum sample pretreatment and without separation of the analytes. The method, based on the PLS1 processing of absorbance data in the UV region, was successfully used for quantification of the drug content of three tablet preparations. The results obtained were in good agreement with HPLC recovery data. The method also enabled determination of drug-dissolution profiles of these commercial tablets, by simultaneous determination of both analytes during the dissolution test.