info:eu-repo/semantics/article
Molecular characterization of XX maleness
Fecha
2019-12Registro en:
Grinspon, Romina; Rey, Rodolfo Alberto; Molecular characterization of XX maleness; Multidisciplinary Digital Publishing Institute; International Journal of Molecular Sciences; 20; 23; 12-2019; 1-22
1661-6596
1422-0067
CONICET Digital
CONICET
Autor
Grinspon, Romina
Rey, Rodolfo Alberto
Resumen
Androgens and anti-Müllerian hormone (AMH), secreted by the foetal testis, are responsible for the development of male reproductive organs and the regression of female anlagen. Virilization of the reproductive tract in association with the absence of Müllerian derivatives in the XX foetus implies the existence of testicular tissue, which can occur in the presence or absence of SRY. Recent advancement in the knowledge of the opposing gene cascades driving to the differentiation of the gonadal ridge into testes or ovaries during early foetal development has provided insight into the molecular explanation of XX maleness.