info:eu-repo/semantics/article
Tinnitus treatment with oxytocin: A pilot study
Fecha
2017-09-21Registro en:
Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; et al.; Tinnitus treatment with oxytocin: A pilot study; Frontiers Research Foundation; Frontiers in Neurology; 8; SEP; 21-9-2017; 1-7; 494
1664-2295
CONICET Digital
CONICET
Autor
Azevedo, Andreia Aparecida
Figueiredo, Ricardo Rodrigues
Elgoyhen, Ana Belen
Langguth, Berthold
Penido, Norma De Oliveira
Schlee, Winfried
Resumen
Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted.