info:eu-repo/semantics/article
Potentiation Effect of Iodine Species on the Antimicrobial Capability of Surfaces Coated with Electroactive Phthalocyanines
Fecha
2021-12Registro en:
Baigorria, Estefanía; Durantini, Javier Esteban; Martinez, Sol Romina; Milanesio, María Elisa; Palacios, Yohana Belén; et al.; Potentiation Effect of Iodine Species on the Antimicrobial Capability of Surfaces Coated with Electroactive Phthalocyanines; American Chemical Society; ACS Applied Bio Materials; 4; 12; 12-2021; 8559-8570
2576-6422
CONICET Digital
CONICET
Autor
Baigorria, Estefanía
Durantini, Javier Esteban
Martinez, Sol Romina
Milanesio, María Elisa
Palacios, Yohana Belén
Durantini, Andres Matías
Resumen
The spreading of different infections can occur through direct contact with glass surfaces in commonly used areas. Incorporating the use of alternative therapies in these materials seems essential to reduce and also avoid bacterial resistance. In this work, the capability to kill microbes of glass surfaces coated with two electroactive metalated phthalocyanines (ZnPc-EDOT and CuPc-EDOT) is assessed. The results show that both of these materials are capable of producing reactive oxygen species; however, the polymer with Zn(II) (ZnPc-PEDOT) has a singlet oxygen quantum yield 8-fold higher than that of the Cu(II) containing analogue. This was reflected in the in vitro experiments where the effectiveness of the surfaces was tested in bacterial suspensions, monitoring single microbe inactivation upon attachment to the polymers, and eliminating mature biofilms. Furthermore, we evaluated the use of an inorganic salt (KI) to potentiate the photodynamic inactivation mediated by an electropolymerized surface. The addition of the salt improved the efficiency of phototherapy at least two times for both polymers; nevertheless, the material coated with ZnPc-PEDOT was the only one capable of eliminating >99.98% of the initial microbes loading under different circumstances.