info:eu-repo/semantics/article
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease
Fecha
2005-07Registro en:
El-Sayed, Najib M.; Myler, Peter J.; Bartholomeu, Daniella C.; Nilsson, Daniel; Aggarwal, Gautam; et al.; The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease; American Association for the Advancement of Science; Science; 309; 5733; 7-2005; 409-415
0036-8075
CONICET Digital
CONICET
Autor
El-Sayed, Najib M.
Myler, Peter J.
Bartholomeu, Daniella C.
Nilsson, Daniel
Aggarwal, Gautam
Tran, Anh-Nhi
Ghedin, Elodie
Worthey, Elizabeth A.
Delcher, Arthur L.
Blandin, Gaëlle
Westenberger, Scott J.
Caler, Elisabet
Cerqueira, Gustavo C.
Branche, Carole
Haas, Brian
Anupama, Atashi
Arner, Erik
Åslund, Lena
Attipoe, Philip
Bontempi, Esteban
Bringaud, Frédéric
Burton, Peter
Cadag, Eithon
Campbell, David A.
Carrington, Mark
Crabtree, Jonathan
Darban, Hamid
Da Silveira, Jose Franco
De Jong, Pieter
Edwards, Kimberly
Englund, Paul T.
Fazelina, Gholam
Feldblyum, Tamara
Ferella, Marcela
Frasch, Alberto Carlos C.
Gull, Keith
Horn, David
Hou, Lihua
Huang, Yiting
Kindlund, Ellen
Klingbeil, Michele
Kluge, Sindy
Koo, Hean
Lacerda, Daniela
Levin, Mariano Jorge
Lorenzi, Hernan
Louie, Tin
Machado, Carlos Renato
McCulloch, Richard
McKenna, Alan
Mizuno, Yumi
Mottram, Jeremy C.
Nelson, Siri
Ochaya, Stephen
Osoegawa, Kazutoyo
Pai, Grace
Parsons, Marilyn
Pentony, Martin
Pettersson, Ulf
Pop, Mihai
Ramirez, Jose Luis
Rinta, Joel
Robertson, Laura
Salzberg, Steven L.
Sanchez, Daniel Oscar
Seyler, Amber
Sharma, Reuben
Shetty, Jyoti
Simpson, Anjana J.
Sisk, Ellen
Tammi, Martti T.
Tarleton, Rick
Teixeira, Santuza
Van Aken, Susan
Vogt, Christy
Ward, Pauline N.
Wickstead, Bill
Wortman, Jennifer
White, Owen
Fraser, Claire M.
Stuart, Kenneth D.
Andersson, Björn
Resumen
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.