info:eu-repo/semantics/article
BiHEA: A hybrid evolutionary approach for microarray biclustering
Fecha
2009-07Registro en:
Gallo, Cristian Andrés; Carballido, Jessica Andrea; Ponzoni, Ignacio; BiHEA: A hybrid evolutionary approach for microarray biclustering; Springer; Lecture Notes in Computer Science; 5676 LNBI; 7-2009; 36-47
978-3-642-03223-3
0302-9743
CONICET Digital
CONICET
Autor
Gallo, Cristian Andrés
Carballido, Jessica Andrea
Ponzoni, Ignacio
Resumen
In this paper a new hybrid approach that integrates an evolutionary algorithm with local search for microarray biclustering is presented. The novelty of this proposal is constituted by the incorporation of two mechanisms: the first one avoids loss of good solutions through generations and overcomes the high degree of overlap in the final population; and the other one preserves an adequate level of genotypic diversity. The performance of the memetic strategy was compared with the results of several salient biclustering algorithms over synthetic data with different overlap degrees and noise levels. In this regard, our proposal achieves results that outperform the ones obtained by the referential methods. Finally, a study on real data was performed in order to demonstrate the biological relevance of the results of our approach. © 2009 Springer Berlin Heidelberg.