info:eu-repo/semantics/article
cis,cis-Germacranolides and melampolides from Mikania thapsoides
Fecha
2003-12Registro en:
Catalan, Cesar Atilio Nazareno; Cuenca, María del R.; Hernandez, Luis Roberto; Joseph Nathan, Pedro; cis,cis-Germacranolides and melampolides from Mikania thapsoides; American Chemical Society; Journal of Natural Products; 66; 7; 12-2003; 949-953
0163-3864
CONICET Digital
CONICET
Autor
Catalan, Cesar Atilio Nazareno
Cuenca, María del R.
Hernandez, Luis Roberto
Joseph Nathan, Pedro
Resumen
The aerial parts of Mikania thapsoides afforded six new cis,cis-germacranolide-type sesquitepene lactones (1-6), of which three (1-3) have an unusual 3,4-epoxy function, and also afforded two new melampolides (7 and 8). All compounds have a trans C-8 lactone ring closure. Their structures were elucidated using 1D and 2D NMR measurements, and the absolute configuration of 1 was determined using the Mosher ester method.