info:eu-repo/semantics/article
Thyroid hormones affect the membrane dipolar organization. Is it a general event in their non-genomic action?
Fecha
2003-02Registro en:
Isse, Blanca Alicia de Los Angeles G.; Fidelio, Gerardo Daniel; Farias, Ricardo Norberto; Thyroid hormones affect the membrane dipolar organization. Is it a general event in their non-genomic action?; Springer; Journal of Membrane Biology; 191; 3; 2-2003; 209-213
0022-2631
CONICET Digital
CONICET
Autor
Isse, Blanca Alicia de Los Angeles G.
Fidelio, Gerardo Daniel
Farias, Ricardo Norberto
Resumen
The surface balance technique was employed to study the interactions of 3,5,3′,5′ tetraiodo L-thyronine, 3,5,3′ triiodo L-thyronine, and 3,5-diiodothyronine with monomolecular phospholipid monolayers spread at the air-water interface. With this technique the insertion of thyroid hormones into egg yolk phosphatidylcholine was investigated. An increase of surface pressure and a substantial decrement in surface potential were observed after the injection of these hormones beneath a phospholipid monolayer. The negative dipole contribution upon hormone interaction opposes the well-known positive contribution of phospholipids. These effects correlated with iodo content of the thyroid molecule analogues 3,5,3′,5′ tetraiodo L-thyronine >3,5,3′ triiodo L-thyronine >3,5-diiodothyronine. To our knowledge, these observations suggest a new and surprising effect of thyroid hormones on the regulation of transmembrane dipolar organization.