info:eu-repo/semantics/article
Clinanthus microstephium, an Amaryllidaceae species with Cholinesterase Inhibitor Alkaloids: Structure−Activity analysis of Haemanthamine skeleton derivatives
Fecha
2019-05Registro en:
Adessi Cofré, Tonino Graziano; Borioni, José Luis; Pigni, Natalia Belen; Bastida, Jaume; Cavallaro, Valeria; et al.; Clinanthus microstephium, an Amaryllidaceae species with Cholinesterase Inhibitor Alkaloids: Structure−Activity analysis of Haemanthamine skeleton derivatives; Wiley VCH Verlag; Chemistry and Biodiversity; 16; 5; 5-2019
1612-1872
1612-1880
CONICET Digital
CONICET
Autor
Adessi Cofré, Tonino Graziano
Borioni, José Luis
Pigni, Natalia Belen
Bastida, Jaume
Cavallaro, Valeria
Murray, Ana Paula
Puiatti, Marcelo
Oberti, Juan Carlos María
Leiva González, Segundo
Nicotra, Viviana Estela
García, Manuela Emila
Resumen
Plants of the Amaryllidaceae family are well-known (not only) for their ornamental value but also for the alkaloids that they produce. In this report, the first phytochemical study of Clinanthus genus was carried out. The chemical composition of alkaloid fractions from Clinanthus microstephium was analyzed by GC/MS and NMR. Seven known compounds belonging to three structural types of Amaryllidaceae alkaloids were identified. An epimeric mixture of a haemanthamine-type compound (6-hydroxymaritidine) was tested as an inhibitor against acetyl- and butyrylcholinesterase enzymes (AChE and BChE, respectively), two enzymes relevant in the treatment of Alzheimer's disease, with good results. Structure–activity relationships through molecular docking studies with this alkaloid and other structurally related compounds were discussed.