info:eu-repo/semantics/article
Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
Fecha
2021-07Registro en:
Mussin, Javier Esteban; Robles Botero, Viviana; Casañas-Pimentel, Rocío; Rojas, Florencia; Angiolella, Letizia; et al.; Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents; Nature; Scientific Reports; 11; 1; 7-2021; 1-12
2045-2322
CONICET Digital
CONICET
Autor
Mussin, Javier Esteban
Robles Botero, Viviana
Casañas-Pimentel, Rocío
Rojas, Florencia
Angiolella, Letizia
San Martín Martínez, Eduardo
Giusiano, Gustavo Emilio
Resumen
Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses.