Argentina
| info:eu-repo/semantics/article
Amphibian skin extracts as source of bioactive multi-target agents against different pathways of Alzheimer’s disease
Fecha
2019Registro en:
Spinelli, Roque; Aimaretti, Florencia Maria; Lopez, Javier Alejandro; Siano, Alvaro Sebastían; Amphibian skin extracts as source of bioactive multi-target agents against different pathways of Alzheimer’s disease; Taylor & Francis Ltd; Natural Product Research; 2019; 1-5
1478-6419
CONICET Digital
CONICET
Autor
Spinelli, Roque
Aimaretti, Florencia Maria
Lopez, Javier Alejandro
Siano, Alvaro Sebastían
Resumen
Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin of anuran amphibians is a rich source of compounds with a wide range of biological activity. Alzheimer´s disease (AD) is a complex disease associated with all kind of different pathways, making their simultaneous modulation necessary. Nowadays anti-AD treatments are focused on enzymatic inhibitors. Here in we report the activity of skin extracts from nine species from Argentina, belonging to three anuran families, as inhibitors of AChE, BChE and MAO-B enzymes. The extracts also showed antioxidant activities, acting as multi-target on four important pathways of AD.