info:eu-repo/semantics/article
Activity of NA+/H+ exchangers alters aquaporin-mediated water transport in human placenta
Fecha
2015-12Registro en:
Dietrich, Valeria; Damiano, Alicia Ermelinda; Activity of NA+/H+ exchangers alters aquaporin-mediated water transport in human placenta; Elsevier; Placenta; 36; 12; 12-2015; 1487-1489
0143-4004
CONICET Digital
CONICET
Autor
Dietrich, Valeria
Damiano, Alicia Ermelinda
Resumen
The intracellular pH (pHi) of syncytiotrophoblasts is regulated, in part, by Na+/H+ exchanger (NHE)-1, NHE-2, and NHE-3. Failures in pHi homeostasis could alter critical cellular functions such as water transport and cell volume. Here, we evaluated whether alterations in syncytiotrophoblast pHi could modify water uptake mediated by aquaporins (AQPs) and the contribution of NHEs to this mechanism. We showed that changes in syncytiotrophoblast pHi did not affect water uptake in the presence of functional NHEs. However, inhibition of NHEs alters transcellular water transport mediated by AQPs in acidosis. These results suggest an interaction between placental AQPs and NHEs in the regulation of water uptake during acidotic states.